Oligopeptide-68 is a decapeptide (containing ten amino acids) with an Arg-Asp-Gly-Gln-Ile-Leu-Ser-Thr-Trp-Tyr sequence, the main active ingredient in β-WHITE™. It is a signal peptide that interacts with MITF (microphthalmia-associated transcription factor), inhibiting melanocyte differentiation and development.
In short, Oligopeptide-68 reduces tyrosinase activity, thereby lessening melanin production and helping fight melasma, hyperpigmentation, and dark spots. Studies showed that it's more effective than hydroquinone, without advanced side effects.
A comparative clinical study of 40 volunteers with hydroquinone (HQ) and Oligopeptide-68 combined with DAB was evaluated at weeks 6 and 12 following controlled radiation exposure. Of the initial cohort, 38 participants completed the study. Among those treated with the peptide-containing formulation, skin whitening effects were rated as significant in 2.6% of subjects, moderate in 76.3%, and slight in 21.1%. These outcomes were superior to those observed in subjects treated with HQ-based creams at 2% and 4% concentrations.
In another study, a combination of Oligopeptide-68 with exfoliating agents showed notable immediate improvement in melasma. That was demonstrated at the cellular level and through clinical observation that didn't reveal adverse effects.Oligopeptide-68 is a safe and effective signaling peptide for skin whitening applications, especially for skin affected by melasma. Usage concentrations are usually 1.0–2.5%.
