Crodasome A/E is a nanoparticle complex loaded with Vitamin A (Retinyl Palmitate) and Vitamin E (Tocopherol Acetate). Isolating the lipophilic interior phase of Vitamins A and E through phospholipids can selectively deposit phospholipids and vitamins onto the stratum corneum, thus increasing skin moisture and improving skin smoothness.
Crodasomes are high-quality nanoparticles whose smaller vesicle size gives them advantages over most other carriers—namely, higher efficacy, better stability, and more aesthetic appeal. They represent an enhanced carrier system for delivering hydrophilic (liposomal) and lipophilic (nanosomal) actives to the skin. Unlike liposomes, nanoparticles allow oil to be incorporated as the internal phase.
Crodasome A/E is a transparent nano-emulsion with an extremely small, well-defined, and uniform particle size. Its nanoparticle consists of an inner oil core encased by an outer unilamellar monolayer composed of natural and purified soy phospholipids.
The phosphatidylcholine content of the phospholipid shell stabilizes the oil-soluble vitamins within the oil core against coalescence. As a sophisticated carrier system, Crodasome A/E provides better availability and more targeted deposition of the vitamin actives.A substantive surfactant isolates the oil core from the formulation vehicle (i.e., external phase), releasing the vitamin actives more effectively onto the skin when the product is applied. The phosphatidylcholine that surrounds the oil core is amphiphilic, meaning it has both hydrophilic and hydrophobic sites that can associate with either polar or nonpolar substrates, such as those found in the stratum corneum.
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