Oligopeptide-104 is a synthetic 11 amino acid-long peptide with sequence Ac-Gln-Gln-Arg-Phe-Glu-Trp-Glu-Phe-Glu-Gln-Gln-NH2 that self-assembles into a 3D matrix with multiple calcium-binding sites as a nucleation point for Hydroxyapatite, triggering the natural tooth regenerative, demineralization, and repair mechanisms. Oligopeptide-104 is used in high-end dental care applications and is known under the trade name Curolox® and scientific name Peptide P11-4.
Hydroxyapatite is the major component of the enamel and dentin's inorganic fraction. Oligopeptide-104 diffuses into lesions on the tooth surface and aggregates, creating numerous nucleation sites for new hydroxyapatite nanocrystals, improving the teeth's mineral density.
Incorporated in toothpaste and teeth care treatments, Oligopeptide-104 boosts remineralization processes, effectively fighting against caries, lesions, and enamel defects. It also helps to form and grow dentin, a hard tissue of the teeth. Positive changes may be achieved after a week or two of treatment.
Comparative studies report lower enamel microhardness and a reduced calcium/phosphate weight ratio in Oligopeptide-104-treated groups relative to other interventions. However, the use of adjunctive agents has demonstrated a synergistic effect, improving results, particularly in enhancing mineral deposition and lesion stabilization.Recovering and protecting the tooth surface, Oligopeptide-104 treats unpleasant sensations and hypersensitivity to temperature changes and sugar. It prevents tooth decay and dentin demineralization.
