Crystalide™

Functions
Skin whitening agent
Exfoliator
Smoothing
CAS Number(s)
887140-79-6
Origin
Synthetic

Crystalide™ is a peptide-based complex by Sederma with an illuminating effect from deeper skin layers to the surface. The concept of "Glass Skin" is a popular trend in modern skincare, referring to translucent, hydrated, luminous skin. This trend stems from illuminating makeup, which is widely used and temporarily makes the complexion appear brighter through optical effects.

Crystalide™ contains a bio-harmonic peptide that promotes α-crystallin, a transparent protein found in the eye lens (about 50% of content), but also distributed in many tissues, including the skin. α-crystallin is a chaperone protein that provides skin transparency and radiance, revealing the "crystalline skin" effect. Palmitoyl Tetrapeptide-10 (sequence Pal-Lys-Thr-Phe-Lys; KTFK) maintains alpha-crystallin proteostasis (the mechanisms that control protein synthesis, folding, degradation, and aggregation), thereby revealing the skin's essential radiance.

In addition, Crystalide™ promotes natural desquamation processes, regulating the rate of epidermal renewal and the pace of keratinocyte maturation, resulting in clearer, even-toned skin. After a harmonious peel, the skin appears uniform, fresh, and radiant like a piece of crystal.

Thanks to a subtle smoothing effect, Crystalide™ makes the skin look smoother and radiant, revealing an excellent, luminous complexion. This complex is used in modern face creams and primers that recreate the skin's radiance, like a highlighter, and help achieve a more uniform tan. Clinical studies showed that it is safe to use on all skin types and tones.
Synonyms
N-Palmitoyl-Lys-Thr-Phe-Lys
Pal-KTFK peptide
Changed

References

An Open‐Label Study Assessing the Efficacy and Tolerability of a Skincare Regimen in Subjects of Different Ethnicities with Moderate‐to‐Severe Hyperpigmentation
Author(s):
,
DOI:
10.1111/jocd.14447
A survey and analysis of the role of molecular chaperone proteins and imidazole-containing dipeptide-based compounds as molecular escorts into the skin during stress, injury, water structuring and other types of cutaneous pathophysiology
Author(s):
, , ,
PMID:
20546050
DOI:
10.1111/j.1468-2494.2010.00601.x
Water-structuring technology with the molecular chaperone proteins: indicated application of the α-crystallin domains and imidazole-containing peptidomimetics in cosmetic skin care systems or dermatological therapeutic drug carrier formulations
Author(s):
, , ,
PMID:
21663576
DOI:
10.1615/critrevtherdrugcarriersyst.v28.i3.10
Evaluation of the sensitive skin syndrome and the effect of a dermo‐cosmetic treatment in Thai and Polish subjects
Author(s):
, , , , , , , , , , ,
DOI:
10.1111/ics.70017