Lycopene

Functions
Antioxidant
Regeneration booster
Microcirculation enhancer
Anti-photoaging
CAS Number(s)
502-65-8
EINECS number(s)
207-949-1
FDA UNII
SB0N2N0WV6
INCI name
Lycopene
Origin
Botanical

Lycopene is the predominant carotenoid (non-provitamin A) derived from fruits and vegetables such as tomatoes, watermelons, and grapefruit. It is one of the most potent antioxidants and helps protect skin from UV-induced and free-radical damage, preventing oxidation of low-density lipoproteins (LDLs), cell membranes, and DNA.

A highly effective antioxidant to guard against photodamage, Lycopene boosts skin's moisturization, enhances texture, and supports elasticity. A carotenoid found in tomatoes and other red fruits and vegetables, the natural compound helps restore and preserve the skin's smoothness, delivering a soft, silky, supple feel.

In vivo studies have shown that when applied topically, Lycopene reduces reactive oxygen species (free radicals), β-galactosidase activity, and advanced glycosylation end products, thereby demonstrating its antioxidant and anti-aging effects. Moreover, it increased the production of Fibrillin-I and VEGF by dermal fibroblasts, stimulating microvessel renewal and blood microcirculation, decreasing insulin resistance in aged skin, and preventing age-related mitochondrial disorders.

When combined with wheat bran extract containing hydroquinone, Lycopene was tested in a skin-lightening cream and showed promising results as a natural alternative to synthetic skin whitening agents. In addition, it reduces erythema and evens skin tone.

It is a safe and natural ingredient for personal care applications. It is used in sun care, anti-acne, protective daily care, and anti-aging applications.

Synonyms
(all-E)-2,6,10,14,19,23,27,31-Octamethyl-2,6,8,10,14,16,18,20,22,24,26,30-Dotriaconatridecaene
Changed

References

Lycopene ameliorates skin aging by regulating the insulin resistance pathway and activating SIRT1
Author(s):
, , ,
PMID:
36226790
DOI:
10.1039/d2fo01111e
The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials
Author(s):
, , , , , , ,
PMID:
36606553
DOI:
10.1080/10408398.2022.2164557
Lycopene as a Potential Bioactive Compound: Chemistry, Extraction, and Anticancer Prospective
Author(s):
,
PMID:
36718971
DOI:
10.2174/1568009623666230131124236
A double-blind, placebo-controlled randomized trial of skin-lightening cream containing lycopene and wheat bran extract on melasma
Author(s):
, , ,
PMID:
33151615
DOI:
10.1111/jocd.13799
Topical delivery of lycopene using microemulsions: enhanced skin penetration and tissue antioxidant activity
Author(s):
, , , , , , , , , , ,
PMID:
19798758
DOI:
10.1002/jps.21929